Preparation and evaluation of porous granules of composite material based agglomerated biogenic hydroxyapatite

Abstract

Porous, highly porous and ultraporous composites based on agglomerated biogenic hydroxyapatite with initial particle sizes of 160—1000 μm and glass-phase reinforced (15—30% (wt.)) were obtained and investigated. The total porosity of the obtained materials is in the range of 42,5—59,5% and decreases with increasing content of the glass phase in the composite. The use of porous granules of biogenic hydroxyapatite to produce composite materials allows preserving the natural porous system, which is present in the initial structure of hydroxyapatite. The open porosity is predominating and decreases from 43,75 to 22,45% with an increase in the glass phase. In vitro studies have shown that in the first 2 days the rate of dissolution of the composites in physiological saline increases with an increase in the content of the glass phase in the material.