Stability of Iron-Based Powders with Different Phase Compositions in Biological Media


I. M. Frantsevich Institute for Problems of Materials Science of the NAS of Ukraine, Omeliana Pritsaka str.,3, Kyiv, 03142, Ukraine
Powder Metallurgy - Kiev: Frantsevich Institute for Problems of Materials Science NASU, 2010, #11/12


The interaction of iron-based powders with different phase compositions with model biomedia is investigated in experiments in vitro. The powders are synthesized from iron oxalates over a range from 450 to 830°C in a carbon-containing atmosphere and from citrates at 390 and 450 °С with prolonged holding in a protective hydrogen medium. The phase composition of the powders is determined using a DRON 3.0 x-ray diffractometer under Со-Кα radiation. Fresh frozen human blood plasma is used as biological media and distilled water and a 0.9% NaCl solution as inorganic media. It is shown that different processes occur in blood plasma and inorganic media: corrosion in water media and interaction between iron and blood plasma protein to form iron-protein complexes in plasma-containing media. The dissolution rate of the powders in blood plasma depends on their α-iron content: the higher the latter, the more active the interaction of the powder with plasma proteins such as ferritin and transferrin, the basic components of the γ-globulin fraction. The powders synthesized via decomposition of citrates at 450 and 390°С with prolonged holding in a protective hydrogen medium interact with the model solutions of digestive juice far more intensely, which makes them promising for the development of iron-containing food supplements.